Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.C182G

c.544T>G

Surrounding Variants

1 paper

NM_000546.6

p.R181insFs

c.542_543dupGC

1 paper

NM_000546.6

p.E180_R181insFs

c.539_543dup5

10 papers

NM_000546.6

p.C182R

c.544T>C

27 papers

NM_000546.6

p.C182S

c.544T>A

1 paper

NM_000546.6

p.R181delFs

c.543delG

1 paper

NM_000546.6

p.P177_R181del0

c.529_543del15

5 papers

NM_000546.6

p.C182fs

c.544_545fs

4 papers

NM_000546.6

p.C182F

c.545G>T

26 papers

NM_000546.6

p.C182S

c.545G>C

18 papers

NM_000546.6

p.C182Y

c.545G>A

2 papers

NM_000546.6

p.C182delFs

c.544delA

6 papers

NM_000546.6

p.R181R

c.543C>T