Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

97 papers

NM_000546.6

p.R181P

c.542G>C

Surrounding Variants

34 papers

NM_000546.6

p.R181L

c.542G>T

239 papers

NM_000546.6

p.R181H

c.542G>A

1 paper

NM_000546.6

p.H179_E180del2

c.535_539del6

183 papers

NM_000546.6

p.R181C

c.541C>T

6 papers

NM_000546.6

p.R181R

c.543C>T

8 papers

NM_000546.6

p.R181G

c.541C>G

1 paper

NM_000546.6

p.R181R

c.543C>G

1 paper

NM_000546.6

p.R174_E180insFs

c.522_540dup19

6 papers

NM_000546.6

p.R181fs

c.541_542fs

1 paper

NM_000546.6

p.R181_C182ins5

c.541_545ins15

13 papers

NM_000546.6

p.R181S

c.541C>A

1 paper

NM_000546.6

p.R181R

c.543C>A