Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

183 papers

NM_000546.6

p.R181C

c.541C>T

Surrounding Variants

8 papers

NM_000546.6

p.R181G

c.541C>G

1 paper

NM_000546.6

p.R174_E180insFs

c.522_540dup19

1 paper

NM_000546.6

p.R181_C182ins5

c.541_545ins15

13 papers

NM_000546.6

p.R181S

c.541C>A

3 papers

NM_000546.6

p.E180delFs

c.540delC

4 papers

NM_000546.6

p.R181fs

c.541_542fs

1 paper

NM_000546.6

p.C176_R181Fs

c.528_541delinsAFs

1 paper

NM_000546.6

p.E171_H179del9

c.511_536del27

34 papers

NM_000546.6

p.R181L

c.542G>T

11 papers

NM_000546.6

p.E180D

c.540G>T

10 papers

NM_000546.6

p.E180fs

c.538_539fs

1 paper

NM_000546.6

p.H179_E180ins0

c.537_539dupTGA