Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.H178_E180del0

c.533_538del6

Surrounding Variants

11 papers

NM_000546.6

p.E180D

c.540G>T

10 papers

NM_000546.6

p.E180fs

c.538_539fs

1 paper

NM_000546.6

p.H179_E180ins0

c.537_539dupTGA

14 papers

NM_000546.6

p.E180D

c.540G>C

5 papers

NM_000546.6

p.E180E

c.540G>A

3 papers

NM_000546.6

p.H179_E180del1

c.536_538delCAT

1 paper

NM_000546.6

p.T170_E180delFs

c.509_539del31

183 papers

NM_000546.6

p.R181C

c.541C>T

8 papers

NM_000546.6

p.R181G

c.541C>G

1 paper

NM_000546.6

p.R174_E180insFs

c.522_540dup19

1 paper

NM_000546.6

p.R181_C182ins5

c.541_545ins15

13 papers

NM_000546.6

p.R181S

c.541C>A