Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.H179H

c.537T>C

Surrounding Variants

11 papers

NM_000546.6

p.H179fs

c.535_536fs

3 papers

NM_000546.6

p.H179insFs

c.536dupA

212 papers

NM_000546.6

p.H179Q

c.537T>G

214 papers

NM_000546.6

p.H179Q

c.537T>A

3 papers

NM_000546.6

p.H179delFs

c.536delT

2 papers

NM_000546.6

p.H178_H179del1

c.534_536delTGG

1 paper

NM_000546.6

p.C176_H179del0

c.528_536del9

55 papers

NM_000546.6

p.E180*

c.538G>T

1 paper

NM_000546.6

p.H179insFs

c.537dupT

1 paper

NM_000546.6

p.H178_H179ins0

c.532_537dup6

1 paper

NM_000546.6

p.E180insFs

c.538_539ins19

10 papers

NM_000546.6

p.E180Q

c.538G>C