Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.P177_H179del0

c.530_535del6

Surrounding Variants

157 papers

NM_000546.6

p.H179L

c.536A>T

611 papers

NM_000546.6

p.H179R

c.536A>G

NM_001126115.2

p.H47R

c.140A>G

49 papers

NM_000546.6

p.H179P

c.536A>C

NM_001276760.3

p.H140P

c.419A>C

4 papers

NM_000546.6

p.H179insFs

c.535_536insC

1 paper

NM_000546.6

p.V173_H179insFs

c.517_535dup19

1 paper

NM_000546.6

p.H179delFs

c.535delG

1 paper

NM_000546.6

p.H178_H179delFs

c.534_535delGG

2 papers

NM_000546.6

p.H178_H179delFs

c.532_535del4

1 paper

NM_000546.6

p.C176_H179del0

c.527_535del9

1 paper

NM_000546.6

p.C176_H179delFs

c.526_535del10

11 papers

NM_000546.6

p.H179fs

c.535_536fs

3 papers

NM_000546.6

p.H179insFs

c.536dupA