Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

55 papers

NM_000546.6

p.H178Q

c.534C>A

Surrounding Variants

8 papers

NM_000546.6

p.H178H

c.534C>T

53 papers

NM_000546.6

p.H178Q

c.534C>G

34 papers

NM_000546.6

p.H178fs

c.532_533fs

NM_001126115.2

p.H46fs

c.136_137fs

2 papers

NM_000546.6

p.H178insFs

c.533dupA

4 papers

NM_000546.6

p.H178delFs

c.533delT

2 papers

NM_000546.6

p.V173_H178delFs

c.518_533del16

9 papers

NM_000546.6

p.H179fs

c.535_536fs

374 papers

NM_000546.6

p.H179Y

c.535C>T

NM_001126115.2

p.H47Y

c.139C>T

87 papers

NM_000546.6

p.H179D

c.535C>G

1 paper

NM_000546.6

p.H179_E180ins6

c.535_539ins18

1 paper

NM_000546.6

p.H179_E180ins12

c.535_539ins36

94 papers

NM_000546.6

p.H179N

c.535C>A