Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.P177del1

c.529_530delGGG

Surrounding Variants

7 papers

NM_000546.6

p.H178L

c.533A>T

9 papers

NM_000546.6

p.H178R

c.533A>G

64 papers

NM_000546.6

p.H178P

c.533A>C

13 papers

NM_000546.6

p.H178insFs

c.532dupC

1 paper

NM_000546.6

p.H178ins1

c.532_533insCCT

1 paper

NM_000546.6

p.P177_H178insFs

c.531_532dupCC

1 paper

NM_000546.6

p.P177_H178ins0

c.530_532dupCCC

1 paper

NM_000546.6

p.H178Fs

c.532_533delinsTFs

36 papers

NM_000546.6

p.H178delFs

c.532delG

2 papers

NM_000546.6

p.C176_P177delFs

c.528_529delGG

1 paper

NM_000546.6

p.C176_H178Fs

c.527_533delinsCCCCCCFs

1 paper

NM_000546.6

p.R175_P177del3

c.523_530del9