Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

38 papers

NM_000546.6

p.H178Y

c.532C>T

Surrounding Variants

74 papers

NM_000546.6

p.H178D

c.532C>G

1 paper

NM_000546.6

p.H178insFs

c.532_533insG

19 papers

NM_000546.6

p.H178N

c.532C>A

1 paper

NM_000546.6

p.P177_H178Fs

c.531_532delinsTFs

1 paper

NM_000546.6

p.C176_P177delFs

c.527_531del5

44 papers

NM_000546.6

p.H178fs

c.532_533fs

7 papers

NM_000546.6

p.P177P

c.531C>T

1 paper

NM_000546.6

p.P177P

c.531C>G

1 paper

NM_000546.6

p.P177_H178insFs

c.531_532insG

2 papers

NM_000546.6

p.P177fs

c.529_530fs

2 papers

NM_000546.6

p.P177P

c.531C>A

1 paper

NM_000546.6

p.P177delins

c.530_531delinsTT