Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

105 papers

NM_000546.6

p.P177R

c.530C>G

Surrounding Variants

94 papers

NM_000546.6

p.P177L

c.530C>T

34 papers

NM_000546.6

p.P177H

c.530C>A

1 paper

NM_000546.6

p.P177delins

c.529_530delinsTT

1 paper

NM_000546.6

p.C176_P177delins

c.528_530delinsGCA

2 papers

NM_000546.6

p.R175_C176del0

c.523_528del6

1 paper

NM_000546.6

p.V172_P177del0

c.515_529del15

60 papers

NM_000546.6

p.P177S

c.529C>T

7 papers

NM_000546.6

p.P177P

c.531C>T

3 papers

NM_000546.6

p.P177A

c.529C>G

1 paper

NM_000546.6

p.P177P

c.531C>G

1 paper

NM_000546.6

p.P177_H178insFs

c.531_532insG

1 paper

NM_000546.6

p.P177ins2

c.529_530ins6