Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P177ins2

c.529_530ins6

Surrounding Variants

60 papers

NM_000546.6

p.P177S

c.529C>T

3 papers

NM_000546.6

p.P177A

c.529C>G

1 paper

NM_000546.6

p.C176_P177insFs

c.528_529insCT

1 paper

NM_000546.6

p.C176ins0

c.526_528dupTGC

1 paper

NM_000546.6

p.P177_H178insGG

c.529_533ins6

1 paper

NM_000546.6

p.P177_H178ins4

c.529_533ins12

25 papers

NM_000546.6

p.P177T

c.529C>A

1 paper

NM_000546.6

p.C176_P177delins

c.528_529delinsTT

2 papers

NM_000546.6

p.C176del1

c.526_528delGCA

1 paper

NM_000546.6

p.R174_C176del3

c.520_527del9

1 paper

NM_000546.6

p.E171_C176del6

c.511_527del18

1 paper

NM_000546.6

p.P177fs

c.529_530fs