Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.C176delins

c.527_528delinsAG

Surrounding Variants

2 papers

NM_000546.6

p.C176C

c.528C>T

104 papers

NM_000546.6

p.C176W

c.528C>G

1 paper

NM_000546.6

p.C176_P177insFs

c.528_529insT

1 paper

NM_000546.6

p.C176insFs

c.527dupG

10 papers

NM_000546.6

p.C176fs

c.526_527fs

44 papers

NM_000546.6

p.C176*

c.528C>A

1 paper

NM_000546.6

p.C176delFs

c.527delC

1 paper

NM_000546.6

p.C176Fs

c.526_528delinsGGFs

472 papers

NM_000546.6

p.C176F

c.527G>T

3 papers

NM_000546.6

p.C176insFs

c.527_528insT

1 paper

NM_000546.6

p.C176insFs

c.527_528insA

153 papers

NM_000546.6

p.C176S

c.527G>C