Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

57 papers

NM_000546.6

p.C176G

c.526T>G

Surrounding Variants

1 paper

NM_000546.6

p.C176insFs

c.526_527insG

1 paper

NM_000546.6

p.R175_C176insFs

c.525_526insC

119 papers

NM_000546.6

p.C176R

c.526T>C

157 papers

NM_000546.6

p.C176S

c.526T>A

1 paper

NM_000546.6

p.R175delFs

c.525delG

1 paper

NM_000546.6

p.R174_R175delFs

c.522_523delGC

2 papers

NM_000546.6

p.R175del1

c.523_524delGCG

2 papers

NM_000546.6

p.R174_R175del2

c.520_524del6

2 papers

NM_000546.6

p.V173_R175del0

c.517_525del9

1 paper

NM_000546.6

p.V172_R175del4

c.514_524del12

1 paper

NM_000546.6

p.H168_R175delFs

c.503_525del23

1 paper

NM_000546.6

p.K164_R175del12

c.490_524del36