Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

13 papers

NM_000546.6

p.R175fs

c.523_524fs

Surrounding Variants

1 paper

NM_000546.6

p.R175R

c.525C>G

1 paper

NM_000546.6

p.R175R

c.525C>A

5 papers

NM_000546.6

p.R175delFs

c.524delC

1 paper

NM_000546.6

p.R174_R175del1

c.521_523delGCC

1 paper

NM_000546.6

p.V173_R175del0

c.519_524del6

1 paper

NM_000546.6

p.V172_R175del0

c.516_524del9

1 paper

NM_000546.6

p.V172_R175delFs

c.514_524del11

1 paper

NM_000546.6

p.C176insFs

c.526_527insG

1 paper

NM_000546.6

p.R175_C176insFs

c.525_526insC

57 papers

NM_000546.6

p.C176G

c.526T>G

119 papers

NM_000546.6

p.C176R

c.526T>C

157 papers

NM_000546.6

p.C176S

c.526T>A