Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

64 papers

NM_000546.6

p.R174W

c.520A>T

Surrounding Variants

12 papers

NM_000546.6

p.R174fs

c.520_521fs

21 papers

NM_000546.6

p.R174G

c.520A>G

1 paper

NM_000546.6

p.R174_R175insC

c.520_524ins3

1 paper

NM_000546.6

p.R174insFs

c.520_521ins22

1 paper

NM_000546.6

p.V173delFs

c.519delC

2 papers

NM_000546.6

p.V173delFs

c.518_519delCA

2 papers

NM_000546.6

p.V173del1

c.517_519delCAC

1 paper

NM_000546.6

p.E171_V173del3

c.511_518del9

1 paper

NM_000546.6

p.S166_V173del0

c.496_519del24

4 papers

NM_000546.6

p.R174M

c.521G>T

1 paper

NM_000546.6

p.V173V

c.519G>T

1 paper

NM_000546.6

p.R174insFs

c.521_522insCG