Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.V172_V173insFs

c.514_517dup4

Surrounding Variants

2 papers

NM_000546.6

p.V173ins1

c.518_519insCGT

78 papers

NM_000546.6

p.V173G

c.518T>G

80 papers

NM_000546.6

p.V173A

c.518T>C

36 papers

NM_000546.6

p.V173E

c.518T>A

4 papers

NM_000546.6

p.V173delFs

c.517delC

1 paper

NM_000546.6

p.V173delins

c.517_518delinsAG

1 paper

NM_000546.6

p.E171_V172del2

c.511_515del6

1 paper

NM_000546.6

p.H168_V173delFs

c.502_517del16

315 papers

NM_000546.6

p.V173L

c.517G>T

1 paper

NM_000546.6

p.V173V

c.519G>T

2 papers

NM_000546.6

p.V172insFs

c.516dupT

1 paper

NM_000546.6

p.V172_V173insFs

c.516_517ins14