Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

307 papers

NM_000546.6

p.V173L

c.517G>C

Surrounding Variants

315 papers

NM_000546.6

p.V173L

c.517G>T

2 papers

NM_000546.6

p.V172insFs

c.516dupT

1 paper

NM_000546.6

p.V172_V173insFs

c.516_517ins14

1 paper

NM_000546.6

p.V173_R174insACT

c.517_521ins9

1 paper

NM_000546.6

p.V173_R174ins16

c.517_521ins48

2 papers

NM_000546.6

p.V173insFs

c.517_518insA

329 papers

NM_000546.6

p.V173M

c.517G>A

1 paper

NM_000546.6

p.V172_V173delins

c.516_517delinsGT

5 papers

NM_000546.6

p.V172delFs

c.515delA

1 paper

NM_000546.6

p.T170_V173Fs

c.510_517delinsAFs

7 papers

NM_000546.6

p.V173fs

c.517_518fs

1 paper

NM_000546.6

p.E171_V172insFs

c.511_515dup5