Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T170_V172delFs

c.508_514del7

Surrounding Variants

1 paper

NM_000546.6

p.E171_V172ins0

c.512_514dupAGG

25 papers

NM_000546.6

p.V172G

c.515T>G

17 papers

NM_000546.6

p.V172A

c.515T>C

63 papers

NM_000546.6

p.V172D

c.515T>A

5 papers

NM_000546.6

p.V172delFs

c.514delC

1 paper

NM_000546.6

p.E171del1

c.511_512delCTC

1 paper

NM_000546.6

p.E171_V172delFs

c.511_514del4

1 paper

NM_000546.6

p.Q167_V172delFs

c.499_514del16

1 paper

NM_000546.6

p.E171_V172insFs

c.511_515dup5

1 paper

NM_000546.6

p.V172Fs

c.516delinsGGTAAGCAAGGTFs

3 papers

NM_000546.6

p.V172fs

c.514_515fs

4 papers

NM_000546.6

p.V172V

c.516T>G