Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.E171_V172insFs

c.513_514insA

Surrounding Variants

14 papers

NM_000546.6

p.E171D

c.513G>T

13 papers

NM_000546.6

p.E171fs

c.511_512fs

14 papers

NM_000546.6

p.E171D

c.513G>C

3 papers

NM_000546.6

p.E171E

c.513G>A

3 papers

NM_000546.6

p.E171delFs

c.512delT

4 papers

NM_000546.6

p.T170_E171delFs

c.509_512del4

4 papers

NM_000546.6

p.V172fs

c.514_515fs

145 papers

NM_000546.6

p.V172F

c.514G>T

1 paper

NM_000546.6

p.V172_V173insT

c.514_518ins3

1 paper

NM_000546.6

p.V172_V173ins4

c.514_518ins12

1 paper

NM_000546.6

p.V172insFs

c.514_515insA

4 papers

NM_000546.6

p.V172L

c.514G>C