Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

11 papers

NM_000546.6

p.E171Q

c.511G>C

NM_001126118.2

p.E132Q

c.394G>C

Surrounding Variants

92 papers

NM_000546.6

p.E171*

c.511G>T

1 paper

NM_000546.6

p.T170insFs

c.509_510dupCG

1 paper

NM_000546.6

p.M169_T170ins0

c.505_510dup6

1 paper

NM_000546.6

p.E171insFs

c.511_512insC

41 papers

NM_000546.6

p.E171K

c.511G>A

1 paper

NM_000546.6

p.T170_E171delins

c.510_511delinsTT

1 paper

NM_000546.6

p.T170_E171delins

c.510_511delinsAT

1 paper

NM_000546.6

p.T170_E171delins

c.510_511delinsAA

2 papers

NM_000546.6

p.T170delFs

c.509_510delCG

4 papers

NM_000546.6

p.T170del1

c.508_509delCGT

7 papers

NM_000546.6

p.E171fs

c.511_512fs

2 papers

NM_000546.6

p.T170T

c.510G>T