Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.M169_T170delFs

c.507_508delTC

Surrounding Variants

59 papers

NM_000546.6

p.T170M

c.509C>T

13 papers

NM_000546.6

p.T170R

c.509C>G

1 paper

NM_000546.6

p.T170insFs

c.508_509insAT

6 papers

NM_000546.6

p.T170K

c.509C>A

1 paper

NM_000546.6

p.I162_M169del8

c.484_506del24

2 papers

NM_000546.6

p.T170T

c.510G>T

2 papers

NM_000546.6

p.T170insFs

c.509dupC

9 papers

NM_000546.6

p.T170fs

c.508_509fs

3 papers

NM_000546.6

p.T170T

c.510G>A

5 papers

NM_000546.6

p.T170delFs

c.509delG

3 papers

NM_000546.6

p.T170fs

c.508_509fs

1 paper

NM_000546.6

p.H168_T170delFs

c.504_508del5