Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.T170fs

c.508_509fs

Surrounding Variants

12 papers

NM_000546.6

p.T170S

c.508A>T

16 papers

NM_000546.6

p.T170A

c.508A>G

NM_001126115.2

p.T38A

c.112A>G

8 papers

NM_000546.6

p.T170P

c.508A>C

1 paper

NM_000546.6

p.H168_M169ins0

c.502_507dup6

1 paper

NM_000546.6

p.T170insFs

c.508_509insGG

1 paper

NM_000546.6

p.T170_E171insGCA

c.508_512ins9

1 paper

NM_000546.6

p.T170_E171ins6

c.508_512ins18

1 paper

NM_000546.6

p.T170_E171ins9

c.508_512ins27

1 paper

NM_000546.6

p.Q165_M169del0

c.495_506del12

1 paper

NM_000546.6

p.A161_M169delFs

c.482_507del26

34 papers

NM_000546.6

p.M169I

c.507G>T

7 papers

NM_000546.6

p.M169fs

c.505_506fs