Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.M169R

c.506T>G

Surrounding Variants

15 papers

NM_000546.6

p.M169T

c.506T>C

7 papers

NM_000546.6

p.M169K

c.506T>A

1 paper

NM_000546.6

p.M169delFs

c.505delT

1 paper

NM_000546.6

p.M169delins

c.505_506delinsTA

1 paper

NM_000546.6

p.H168delFs

c.503_504delGT

1 paper

NM_000546.6

p.S166_Q167delFs

c.497_501del5

34 papers

NM_000546.6

p.M169I

c.507G>T

7 papers

NM_000546.6

p.M169fs

c.505_506fs

33 papers

NM_000546.6

p.M169I

c.507G>C

34 papers

NM_000546.6

p.M169I

c.507G>A

1 paper

NM_000546.6

p.M169delFs

c.506delA

1 paper

NM_000546.6

p.M169delFs

c.505_506delAT