Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.M169L

c.505A>T

Surrounding Variants

5 papers

NM_000546.6

p.M169fs

c.505_506fs

15 papers

NM_000546.6

p.M169V

c.505A>G

5 papers

NM_000546.6

p.M169L

c.505A>C

1 paper

NM_000546.6

p.M169insFs

c.505_506ins5

1 paper

NM_000546.6

p.H168_M169delins

c.504_505delinsTG

4 papers

NM_000546.6

p.H168delFs

c.504delG

9 papers

NM_000546.6

p.M169R

c.506T>G

15 papers

NM_000546.6

p.M169T

c.506T>C

7 papers

NM_000546.6

p.M169K

c.506T>A

1 paper

NM_000546.6

p.M169delFs

c.505delT

1 paper

NM_000546.6

p.M169delins

c.505_506delinsTA

1 paper

NM_000546.6

p.H168delFs

c.503_504delGT