Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.H168delins

c.504delinsGCAG

Surrounding Variants

5 papers

NM_000546.6

p.H168H

c.504C>T

12 papers

NM_000546.6

p.H168Q

c.504C>G

1 paper

NM_000546.6

p.H168_M169insFs

c.504_505insTG

6 papers

NM_000546.6

p.H168fs

c.502_503fs

11 papers

NM_000546.6

p.H168Q

c.504C>A

5 papers

NM_000546.6

p.H168delFs

c.503delT

5 papers

NM_000546.6

p.M169fs

c.505_506fs

47 papers

NM_000546.6

p.H168L

c.503A>T

5 papers

NM_000546.6

p.M169L

c.505A>T

147 papers

NM_000546.6

p.H168R

c.503A>G

15 papers

NM_000546.6

p.M169V

c.505A>G

47 papers

NM_000546.6

p.H168P

c.503A>C