Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

47 papers

NM_000546.6

p.H168P

c.503A>C

Surrounding Variants

47 papers

NM_000546.6

p.H168L

c.503A>T

147 papers

NM_000546.6

p.H168R

c.503A>G

2 papers

NM_000546.6

p.H168delFs

c.502delG

1 paper

NM_000546.6

p.Q167_H168delins

c.499_503delinsTACCT

1 paper

NM_000546.6

p.A161_H168delFs

c.483_502del20

29 papers

NM_000546.6

p.H168Y

c.502C>T

5 papers

NM_000546.6

p.H168H

c.504C>T

12 papers

NM_000546.6

p.H168Q

c.504C>G

7 papers

NM_000546.6

p.H168D

c.502C>G

1 paper

NM_000546.6

p.H168delins

c.504delinsGCAG

1 paper

NM_000546.6

p.Q167insFs

c.501dupG

1 paper

NM_000546.6

p.H168_M169insFs

c.504_505insTG