Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.Q167L

c.500A>T

Surrounding Variants

17 papers

NM_000546.6

p.Q167R

c.500A>G

14 papers

NM_000546.6

p.Q167P

c.500A>C

1 paper

NM_000546.6

p.Q167insFs

c.499dupC

3 papers

NM_000546.6

p.Q167delFs

c.499delG

2 papers

NM_000546.6

p.T155_Q167delFs

c.465_499del35

12 papers

NM_000546.6

p.Q167H

c.501G>T

23 papers

NM_000546.6

p.Q167fs

c.499_500fs

1 paper

NM_000546.6

p.Q167insFs

c.500dupA

1 paper

NM_000546.6

p.Q167insFs

c.499_500dupCA

13 papers

NM_000546.6

p.Q167H

c.501G>C

5 papers

NM_000546.6

p.Q167Q

c.501G>A

1 paper

NM_000546.6

p.Q167delFs

c.500delT