Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

11 papers

NM_000546.6

p.Q167K

c.499C>A

Surrounding Variants

24 papers

NM_000546.6

p.Q167fs

c.499_500fs

137 papers

NM_000546.6

p.Q167*

c.499C>T

NM_001126118.2

p.Q128*

c.382C>T

12 papers

NM_000546.6

p.Q167E

c.499C>G

1 paper

NM_000546.6

p.Q167ins1

c.499_500insGAC

5 papers

NM_000546.6

p.S166insFs

c.498dupA

1 paper

NM_000546.6

p.S166ins3

c.497_498ins9

1 paper

NM_000546.6

p.Q165_S166delFs

c.495_498del4

8 papers

NM_000546.6

p.Q167L

c.500A>T

1 paper

NM_000546.6

p.S166S

c.498A>T

17 papers

NM_000546.6

p.Q167R

c.500A>G

3 papers

NM_000546.6

p.S166S

c.498A>G

14 papers

NM_000546.6

p.Q167P

c.500A>C