Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.S166fs

c.496_497fs

Surrounding Variants

1 paper

NM_000546.6

p.S166S

c.498A>T

3 papers

NM_000546.6

p.S166S

c.498A>G

1 paper

NM_000546.6

p.S166insFs

c.497dupC

1 paper

NM_000546.6

p.S166Fs

c.496_498delinsGFs

2 papers

NM_000546.6

p.A159_S166del0

c.477_497del21

24 papers

NM_000546.6

p.Q167fs

c.499_500fs

137 papers

NM_000546.6

p.Q167*

c.499C>T

NM_001126118.2

p.Q128*

c.382C>T

20 papers

NM_000546.6

p.S166L

c.497C>T

76 papers

NM_000546.6

p.S166*

c.497C>G

12 papers

NM_000546.6

p.Q167E

c.499C>G

1 paper

NM_000546.6

p.S166insFs

c.497_498insT

1 paper

NM_000546.6

p.Y163_S166ins1

c.488_496dup9