Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.Q165_S166delFs

c.495_496delAC

Surrounding Variants

20 papers

NM_000546.6

p.S166L

c.497C>T

76 papers

NM_000546.6

p.S166*

c.497C>G

1 paper

NM_000546.6

p.S166insFs

c.497_498insT

1 paper

NM_000546.6

p.Y163_S166ins1

c.488_496dup9

1 paper

NM_000546.6

p.S166ins4

c.497_498ins12

77 papers

NM_000546.6

p.S166*

c.497C>A

2 papers

NM_000546.6

p.S166delins

c.496_497delinsGG

1 paper

NM_000546.6

p.S166delFs

c.496delA

1 paper

NM_000546.6

p.Q165_S166Fs

c.494_497delinsTCTGTFs

1 paper

NM_000546.6

p.Q165ins0

c.493_495dupCAG

1 paper

NM_000546.6

p.S166ins3

c.496_497ins9

1 paper

NM_000546.6

p.S166_Q167ins5

c.496_500ins15