Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Q165ins0

c.493_495dupCAG

Surrounding Variants

1 paper

NM_000546.6

p.S166ins3

c.496_497ins9

1 paper

NM_000546.6

p.S166_Q167ins5

c.496_500ins15

1 paper

NM_000546.6

p.S166_Q167ins14

c.496_500ins42

11 papers

NM_000546.6

p.S166A

c.496T>G

15 papers

NM_000546.6

p.S166P

c.496T>C

12 papers

NM_000546.6

p.S166T

c.496T>A

2 papers

NM_000546.6

p.Q165delFs

c.495delC

1 paper

NM_000546.6

p.S166fs

c.496_497fs

11 papers

NM_000546.6

p.Q165H

c.495G>T

11 papers

NM_000546.6

p.Q165fs

c.493_494fs

1 paper

NM_000546.6

p.Q165insFs

c.494dupA

1 paper

NM_000546.6

p.R156_Q165insFs

c.466_494dup29