Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

165 papers

NM_000546.6

p.Q165*

c.493C>T

Surrounding Variants

10 papers

NM_000546.6

p.Q165fs

c.493_494fs

8 papers

NM_000546.6

p.Q165E

c.493C>G

1 paper

NM_000546.6

p.Q165_S166insYKQ

c.493_497ins9

22 papers

NM_000546.6

p.Q165K

c.493C>A

3 papers

NM_000546.6

p.K164_Q165delins

c.492_493delinsTT

2 papers

NM_000546.6

p.K164_Q165delins

c.492_493delinsCT

3 papers

NM_000546.6

p.K164delFs

c.492delC

1 paper

NM_000546.6

p.T155_K164del10

c.463_491del30

1 paper

NM_000546.6

p.G154_K164delFs

c.461_492del32

27 papers

NM_000546.6

p.K164N

c.492G>T

NM_001126118.2

p.K125N

c.375G>T

9 papers

NM_000546.6

p.K164fs

c.490_491fs

1 paper

NM_000546.6

p.K164_Q165ins3

c.492_493ins9