Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

13 papers

NM_000546.6

p.K164M

c.491A>T

Surrounding Variants

27 papers

NM_000546.6

p.K164R

c.491A>G

10 papers

NM_000546.6

p.K164T

c.491A>C

1 paper

NM_000546.6

p.Y163_K164delFs

c.489_490delTG

1 paper

NM_000546.6

p.A161_K164del0

c.482_490del9

2 papers

NM_000546.6

p.R158_K164del0

c.473_490del18

27 papers

NM_000546.6

p.K164N

c.492G>T

NM_001126118.2

p.K125N

c.375G>T

9 papers

NM_000546.6

p.K164fs

c.490_491fs

1 paper

NM_000546.6

p.K164_Q165ins3

c.492_493ins9

25 papers

NM_000546.6

p.K164N

c.492G>C

6 papers

NM_001126118.2

p.K125K

c.375G>A

NM_000546.6

p.K164K

c.492G>A

7 papers

NM_000546.6

p.K164delFs

c.491delT

15 papers

NM_000546.6

p.K164fs

c.490_491fs