Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

51 papers

NM_000546.6

p.Y163*

c.489C>A

Surrounding Variants

1 paper

NM_000546.6

p.Y163Y

c.489C>T

51 papers

NM_000546.6

p.Y163*

c.489C>G

4 papers

NM_000546.6

p.Y163fs

c.487_488fs

15 papers

NM_000546.6

p.K164fs

c.490_491fs

38 papers

NM_000546.6

p.K164*

c.490A>T

6 papers

NM_000546.6

p.Y163F

c.488A>T

534 papers

NM_000546.6

p.Y163C

c.488A>G

103 papers

NM_000546.6

p.K164E

c.490A>G

36 papers

NM_000546.6

p.Y163S

c.488A>C

11 papers

NM_000546.6

p.K164Q

c.490A>C

1 paper

NM_000546.6

p.K164insFs

c.490_491insGT

1 paper

NM_000546.6

p.Y163insFs

c.488_489insTA