Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.I162_Y163delins

c.486_488delinsCAC

Surrounding Variants

6 papers

NM_000546.6

p.Y163F

c.488A>T

534 papers

NM_000546.6

p.Y163C

c.488A>G

36 papers

NM_000546.6

p.Y163S

c.488A>C

1 paper

NM_000546.6

p.Y163insFs

c.488_489insTA

1 paper

NM_000546.6

p.I162_Y163del1

c.485_487delAGA

1 paper

NM_000546.6

p.A161_Y163del0

c.482_487del6

1 paper

NM_000546.6

p.R158_Y163Fs

c.474_488delinsGGGGCFs

1 paper

NM_000546.6

p.I162insFs

c.486dupC

1 paper

NM_000546.6

p.I162ins0

c.484_486dupATC

42 papers

NM_000546.6

p.Y163D

c.487T>G

107 papers

NM_000546.6

p.Y163H

c.487T>C

65 papers

NM_000546.6

p.Y163N

c.487T>A