Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.I162ins0

c.484_486dupATC

Surrounding Variants

1 paper

NM_000546.6

p.I162insFs

c.486dupC

42 papers

NM_000546.6

p.Y163D

c.487T>G

107 papers

NM_000546.6

p.Y163H

c.487T>C

65 papers

NM_000546.6

p.Y163N

c.487T>A

3 papers

NM_000546.6

p.I162delFs

c.486delG

2 papers

NM_000546.6

p.A161_I162del2

c.481_485del6

1 paper

NM_000546.6

p.M160_Y163delins

c.478_487delinsCTTTTCCATCAAC

1 paper

NM_000546.6

p.R158_I162del0

c.472_486del15

1 paper

NM_000546.6

p.V157_I162del6

c.469_485del18

5 papers

NM_000546.6

p.Y163fs

c.487_488fs

4 papers

NM_000546.6

p.I162I

c.486C>T

14 papers

NM_000546.6

p.I162M

c.486C>G