Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.I162delFs

c.484delT

Surrounding Variants

1 paper

NM_000546.6

p.I162insFs

c.485_486ins4

1 paper

NM_000546.6

p.V157_I162insFs

c.469_484dup16

33 papers

NM_000546.6

p.I162S

c.485T>G

16 papers

NM_000546.6

p.I162T

c.485T>C

41 papers

NM_000546.6

p.I162N

c.485T>A

1 paper

NM_000546.6

p.A161_I162delFs

c.483_484delTG

1 paper

NM_000546.6

p.R158_I162delFs

c.474_484del11

1 paper

NM_000546.6

p.R158_I162del0

c.473_484del12

1 paper

NM_000546.6

p.T155_I162del0

c.464_484del21

4 papers

NM_000546.6

p.I162I

c.486C>T

14 papers

NM_000546.6

p.I162M

c.486C>G

8 papers

NM_000546.6

p.I162fs

c.484_485fs