Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.R158_A161del0

c.472_483del12

Surrounding Variants

10 papers

NM_000546.6

p.I162fs

c.484_485fs

61 papers

NM_000546.6

p.I162F

c.484A>T

11 papers

NM_000546.6

p.I162V

c.484A>G

6 papers

NM_000546.6

p.I162L

c.484A>C

1 paper

NM_000546.6

p.M160_A161insFs

c.479_483dup5

1 paper

NM_000546.6

p.A159_A161insFs

c.477_483dup7

1 paper

NM_000546.6

p.R158_A161insFs

c.473_483dup11

1 paper

NM_000546.6

p.I162_Y163insC

c.484_488ins3

3 papers

NM_000546.6

p.A161delFs

c.483delG

1 paper

NM_000546.6

p.A161delFs

c.482_483delGG

2 papers

NM_000546.6

p.A161del1

c.481_482delGGC

1 paper

NM_000546.6

p.R158_A161delFs

c.473_483del11