Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.V157_M160del4

c.469_479del12

Surrounding Variants

45 papers

NM_000546.6

p.A161V

c.482C>T

15 papers

NM_000546.6

p.A161G

c.482C>G

2 papers

NM_000546.6

p.A161insFs

c.482_483insG

1 paper

NM_000546.6

p.A159_A161insFs

c.475_481dup7

74 papers

NM_000546.6

p.A161D

c.482C>A

6 papers

NM_000546.6

p.A161delFs

c.481delC

58 papers

NM_000546.6

p.A161S

c.481G>T

1 paper

NM_000546.6

p.A161_I162insT

c.481_485ins3

16 papers

NM_000546.6

p.A161P

c.481G>C

239 papers

NM_000546.6

p.A161T

c.481G>A

1 paper

NM_000546.6

p.M160_A161delins

c.480_481delinsTT

1 paper

NM_000546.6

p.V157_M160delFs

c.471_480del10