Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

58 papers

NM_000546.6

p.A161S

c.481G>T

Surrounding Variants

1 paper

NM_000546.6

p.A161_I162insT

c.481_485ins3

16 papers

NM_000546.6

p.A161P

c.481G>C

239 papers

NM_000546.6

p.A161T

c.481G>A

1 paper

NM_000546.6

p.M160_A161delins

c.480_481delinsTT

1 paper

NM_000546.6

p.V157_M160delFs

c.471_480del10

1 paper

NM_000546.6

p.R156_M160del5

c.466_479del15

1 paper

NM_000546.6

p.L145_M160del16

c.433_479del48

9 papers

NM_000546.6

p.A161fs

c.481_482fs

46 papers

NM_000546.6

p.M160I

c.480G>T

8 papers

NM_000546.6

p.M160fs

c.478_479fs

47 papers

NM_000546.6

p.M160I

c.480G>C

49 papers

NM_000546.6

p.M160I

c.480G>A