Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.M160insFs

c.478dupA

Surrounding Variants

1 paper

NM_000546.6

p.R158_M160ins1

c.473_478dup6

8 papers

NM_000546.6

p.M160R

c.479T>G

11 papers

NM_000546.6

p.M160T

c.479T>C

14 papers

NM_000546.6

p.M160K

c.479T>A

3 papers

NM_000546.6

p.M160delFs

c.478delT

1 paper

NM_000546.6

p.A159_M160delFs

c.477_478delTG

1 paper

NM_000546.6

p.R158_M160Fs

c.472_479delinsAFs

1 paper

NM_000546.6

p.V157_M160delFs

c.471_478del8

1 paper

NM_000546.6

p.V157_M160delFs

c.469_478del10

2 papers

NM_000546.6

p.T155_M160del0

c.464_478del15

1 paper

NM_000546.6

p.T150_M160delFs

c.450_478del29

46 papers

NM_000546.6

p.M160I

c.480G>T