Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P152_A159delFs

c.456_475del20

Surrounding Variants

210 papers

NM_000546.6

p.A159V

c.476C>T

13 papers

NM_000546.6

p.A159G

c.476C>G

1 paper

NM_000546.6

p.A159insFs

c.476_477insG

6 papers

NM_000546.6

p.A159ins2

c.476_477ins6

72 papers

NM_000546.6

p.A159D

c.476C>A

1 paper

NM_000546.6

p.A159delins

c.475_476delinsTT

1 paper

NM_000546.6

p.A159delFs

c.475delC

1 paper

NM_000546.6

p.R158_A159delins

c.473_476delinsA

5 papers

NM_000546.6

p.V157_A159del0

c.470_475del6

1 paper

NM_000546.6

p.G154_R158del0

c.460_474del15

24 papers

NM_000546.6

p.A159S

c.475G>T

2 papers

NM_000546.6

p.R158insFs

c.474dupC