Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.R158del1

c.472_473delGCG

Surrounding Variants

24 papers

NM_000546.6

p.A159S

c.475G>T

2 papers

NM_000546.6

p.R158insFs

c.474dupC

152 papers

NM_000546.6

p.A159P

c.475G>C

32 papers

NM_000546.6

p.A159T

c.475G>A

1 paper

NM_000546.6

p.R156_R158del3

c.466_473del9

1 paper

NM_000546.6

p.T155_R158delFs

c.465_474del10

3 papers

NM_000546.6

p.T155_R158del0

c.463_474del12

1 paper

NM_000546.6

p.G154_R158delFs

c.462_474del13

6 papers

NM_000546.6

p.A159fs

c.475_476fs

210 papers

NM_000546.6

p.A159V

c.476C>T

9 papers

NM_000546.6

p.R158R

c.474C>T

13 papers

NM_000546.6

p.A159G

c.476C>G