Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R156_R158delFs

c.467_473del7

Surrounding Variants

9 papers

NM_000546.6

p.R158R

c.474C>T

1 paper

NM_000546.6

p.R158insFs

c.473dupG

24 papers

NM_000546.6

p.R158fs

c.472_473fs

1 paper

NM_000546.6

p.R158_A159ins11

c.474_475ins33

1 paper

NM_000546.6

p.R158_A159insFs

c.474_475insA

3 papers

NM_000546.6

p.R158delins

c.473_474delinsTT

3 papers

NM_000546.6

p.R158delFs

c.473delC

1 paper

NM_000546.6

p.T150_R158del0

c.450_473del24

319 papers

NM_000546.6

p.R158L

c.473G>T

24 papers

NM_000546.6

p.A159S

c.475G>T

1 paper

NM_000546.6

p.R158insFs

c.473_474ins4

1 paper

NM_000546.6

p.R158ins2

c.473_474ins6