Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

15 papers

NM_000546.6

p.R158delFs

c.472delG

Surrounding Variants

319 papers

NM_000546.6

p.R158L

c.473G>T

1 paper

NM_000546.6

p.R158insFs

c.473_474ins4

1 paper

NM_000546.6

p.R158ins2

c.473_474ins6

1 paper

NM_000546.6

p.V157_R158insFs

c.471_472insC

1 paper

NM_000546.6

p.V157_R158insFs

c.471_472dupCC

111 papers

NM_000546.6

p.R158P

c.473G>C

412 papers

NM_000546.6

p.R158H

c.473G>A

NM_001276760.3

p.R119H

c.356G>A

2 papers

NM_000546.6

p.R156_R158delFs

c.466_472del7

149 papers

NM_000546.6

p.R158C

c.472C>T

NM_001276760.3

p.R119C

c.355C>T

9 papers

NM_000546.6

p.R158R

c.474C>T

101 papers

NM_000546.6

p.R158G

c.472C>G

NM_001126115.2

p.R26G

c.76C>G

1 paper

NM_000546.6

p.R158insFs

c.473dupG