Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.V157ins0

c.469_471dupGTC

Surrounding Variants

149 papers

NM_000546.6

p.R158C

c.472C>T

NM_001276760.3

p.R119C

c.355C>T

101 papers

NM_000546.6

p.R158G

c.472C>G

NM_001126115.2

p.R26G

c.76C>G

1 paper

NM_000546.6

p.V157insFs

c.470_471dupTC

1 paper

NM_000546.6

p.R158ins1

c.472_473insTCC

3 papers

NM_000546.6

p.R158ins1

c.472_473ins3

1 paper

NM_000546.6

p.R158_A159ins4

c.472_476ins12

18 papers

NM_000546.6

p.R158S

c.472C>A

16 papers

NM_000546.6

p.R158fs

c.472_473fs

1 paper

NM_000546.6

p.V157_R158delins

c.471_472delinsTT

2 papers

NM_000546.6

p.V157del1

c.469_471delGAC

1 paper

NM_000546.6

p.T155_V157del0

c.463_471del9

1 paper

NM_000546.6

p.G154_R158delins

c.462_472delinsGT