Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

63 papers

NM_000546.6

p.V157D

c.470T>A

Surrounding Variants

1 paper

NM_000546.6

p.V157insFs

c.469_470insG

88 papers

NM_000546.6

p.V157G

c.470T>G

41 papers

NM_000546.6

p.V157A

c.470T>C

1 paper

NM_000546.6

p.V157delFs

c.469delC

2 papers

NM_000546.6

p.R156_V157delFs

c.468_469delCG

1 paper

NM_000546.6

p.P153_V157delFs

c.459_469del11

590 papers

NM_000546.6

p.V157F

c.469G>T

2 papers

NM_000546.6

p.V157insFs

c.469_470insC

1 paper

NM_000546.6

p.P153_R156insFs

c.458_468dup11

1 paper

NM_000546.6

p.R156_V157insFs

c.468_469ins11

31 papers

NM_000546.6

p.V157L

c.469G>C

101 papers

NM_000546.6

p.V157I

c.469G>A