Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T155_R156delins

c.464_467delinsA

Surrounding Variants

13 papers

NM_000546.6

p.R156L

c.467G>T

1 paper

NM_000546.6

p.T155_R156insFs

c.465_466dupCC

1 paper

NM_000546.6

p.T155_R156insFs

c.463_466dup4

1 paper

NM_000546.6

p.P152_R156insFs

c.454_466dup13

141 papers

NM_000546.6

p.R156P

c.467G>C

NM_001276760.3

p.R117P

c.350G>C

96 papers

NM_000546.6

p.R156H

c.467G>A

5 papers

NM_000546.6

p.R156delFs

c.466delG

1 paper

NM_000546.6

p.T155_R156delFs

c.465_466delGG

1 paper

NM_000546.6

p.T155_R156delFs

c.463_466del4

19 papers

NM_000546.6

p.P152_R156delFs

c.454_466del13

1 paper

NM_000546.6

p.S149_R156delFs

c.445_466del22

57 papers

NM_000546.6

p.R156C

c.466C>T