Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

57 papers

NM_000546.6

p.R156C

c.466C>T

Surrounding Variants

39 papers

NM_000546.6

p.R156G

c.466C>G

2 papers

NM_000546.6

p.R156_V157insA

c.466_470ins3

12 papers

NM_000546.6

p.R156S

c.466C>A

18 papers

NM_000546.6

p.R156fs

c.466_467fs

1 paper

NM_000546.6

p.T155_R156delins

c.465_466delinsTT

1 paper

NM_000546.6

p.T155del1

c.463_464delGGT

2 papers

NM_000546.6

p.G154_T155del2

c.460_464del6

1 paper

NM_000546.6

p.P153_R156Fs

c.457_466delinsGGTFs

1 paper

NM_000546.6

p.P152_T155delFs

c.456_465del10

13 papers

NM_000546.6

p.R156L

c.467G>T

1 paper

NM_000546.6

p.T155_R156insFs

c.465_466dupCC

1 paper

NM_000546.6

p.T155_R156insFs

c.463_466dup4