Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.T155T

c.465C>G

Surrounding Variants

9 papers

NM_000546.6

p.T155T

c.465C>T

7 papers

NM_000546.6

p.T155fs

c.463_464fs

6 papers

NM_000546.6

p.T155T

c.465C>A

1 paper

NM_000546.6

p.T155delins

c.464_465delinsTT

2 papers

NM_000546.6

p.T155delFs

c.463_464delGT

1 paper

NM_000546.6

p.P151_T155Fs

c.452_465delinsAAGAFs

71 papers

NM_000546.6

p.T155I

c.464C>T

57 papers

NM_000546.6

p.R156C

c.466C>T

39 papers

NM_000546.6

p.R156G

c.466C>G

22 papers

NM_000546.6

p.T155S

c.464C>G

2 papers

NM_000546.6

p.R156_V157insA

c.466_470ins3

1 paper

NM_000546.6

p.Q144_T155insFs

c.432_463dup32